Monday, February 13, 2012

SUMMARY of alleged image manipulation

Article No.1: Mol Cell. 2004 Jun 4;14(5):571-83.
PubPeer: https://pubpeer.com/publications/15175153

Article No.2: Science. 2004 Oct 8;306(5694):271-5.
PubPeer: https://pubpeer.com/publications/15358865

Article No.3:  Mol Cell. 2005 Dec 22;20(6):891-903.
PubPeer: https://pubpeer.com/publications/16364914

Article No.4:  Cell. 2006 Feb 10;124(3):601-13.
Pubpeer: https://pubpeer.com/publications/16469705

Article No.5: Immunity. 2006 Sep;25(3):403-15.
PubPeer: https://pubpeer.com/publications/16973390

Article No.6: Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1717-22.
PubPeer: https://pubpeer.com/publications/16446428

Article No.7:  Nature. 2007 Apr 5;446(7136):690-4.
PubPeer: https://pubpeer.com/publications/17377533

Article No.6:   Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2487-92.
PubPeer: https://pubpeer.com/publications/18268325

Article No.7:  Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7803-8.
PubPeer: https://pubpeer.com/publications/18511561

Article No.8:  Cancer Cell. 2010 Mar 16;17(3):286-97.
PubPeer: https://pubpeer.com/publications/20227042

Article No.9:  J Exp Med. 2011 Aug 29;208(9):1889-900.
PubPeer: https://pubpeer.com/publications/21825016

Article No.10: Nature. 2012 Nov 8;491(7423):254-8.
PubPeer: https://pubpeer.com/publications/23034650

Saturday, February 11, 2012

Jun turnover is controlled through JNK-dependent phosphorylation of theE3 ligase Itch.

Science. 2004 Oct 8;306(5694):271-5. Epub 2004 Sep 9.

Jun turnover is controlled through JNK-dependent phosphorylation of theE3 ligase Itch.

Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M.

Source

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA.

Source

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

Mol Cell. 2004 Jun 4;14(5):571-83.

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY.

Source

Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132 Genoa, Italy. rgherzi@yahoo.com

Source

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

Cell. 2006 Feb 10;124(3):601-13.

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M.

Division of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E. Duarte Road, KCRB 3009, Duarte, CA 91010, USA.

PubPeer: https://pubpeer.com/publications/26BF1A9A41412947E05D956E91F161

Source

Fig. 2 - View high quality image (639K)

Source

https://pubpeer.com/publications/26BF1A9A41412947E05D956E91F161#fb8006

Cells in Fig.3D look very similar to cells in Fig.4A, but they are supposed to be of different genotypes, and transfected and treated differently.
http://imgur.com/2A2CUHV

Source

https://pubpeer.com/publications/26BF1A9A41412947E05D956E91F161#fb8052

In Fig. 1A, the 12.5 day WT and double mutant embryos are the same. See the identical light reflections.

http://i.imgur.com/oEWRbgg.png

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.

Nature. 2007 Apr 5;446(7136):690-4. Epub 2007 Mar 18.

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.

Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M.

Source

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA.

Erratum in

Nature. 2009 Feb 12;457(7231):920.

It has come to our attention that some of the control lanes in Fig. 2a (Kai1 and Mkk4 control lanes) may
have been inadvertently duplicated during figure assembly;
the other control lanes and the experimental Maspin lanes are correct.
We have therefore repeated the experiments and obtained the same results as those in the published figure.
The primary data from this experiment can be found in Supplementary Information.

どこが複製されている画像なのでしょうか？

Alternative and classical NF-kappa B signaling retain autoreactive B cells in thesplenic marginal zone and result in lupus-like disease.

Immunity. 2006 Sep;25(3):403-15.

Alternative and classical NF-kappa B signaling retain autoreactive B cells in thesplenic marginal zone and result in lupus-like disease.

Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M.

Source

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

Source

Fig.6　View high quality image (1010K)