tag:blogger.com,1999:blog-86761923990077599512024-03-13T09:57:11.589+09:00Michael KarinAlleged image fraud at Michael Karin laboratory11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-8676192399007759951.post-22461425130718739612012-02-13T10:36:00.000+09:002014-05-02T09:30:34.144+09:00SUMMARY of alleged image manipulation<br />
<span style="background-color: white;"><span lang="EN-US" style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;"><b style="background-color: transparent;"><span style="background-color: white; color: #333333;"><span lang="EN-US" style="background-color: white;"><span style="line-height: 24px;">Article No.</span><span style="line-height: 18px;">1</span></span></span></b><b style="color: black; font-family: 'MS PGothic'; line-height: normal;"><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="background-color: transparent; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="background-color: white; line-height: 19px;"> </span></span></b></span></span><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;"><a href="http://karinlab-et-al.blogspot.com/2012/02/kh-domain-rna-binding-protein-ksrp.html">Mol Cell. 2004 Jun 4;14(5):571-83.</a></span></span></b><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/15175153">https://pubpeer.com/publications/15175153</a></span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;"><b><span style="background-color: white; color: #333333; line-height: 24px;"><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-color: white; background-image: initial; background-origin: initial;">Article No.<span style="line-height: 18px;">2</span></span></span></b></span><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;"><a href="http://karinlab-et-al.blogspot.com/2012/02/jun-turnover-is-controlled-through-jnk.html">Science. 2004 Oct 8;306(5694):271-5.</a></span></span></b><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/15358865">https://pubpeer.com/publications/15358865</a></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">3</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333; line-height: 24px;"><span style="line-height: 19px;"> </span></span></span></b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 19px;"><b>Mol Cell. 2005 Dec 22;20(6):891-903.</b></span></span><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/16364914">https://pubpeer.com/publications/16364914</a></span><br />
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<span style="color: red;"><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white;"><span lang="EN-US" style="background-color: white;"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">4</span></span></span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white;"><span style="line-height: 19px;"> </span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; line-height: 24px;"><span style="background-color: white; line-height: 19px;"> </span></span></span></b></span><b style="font-family: Arial, Helvetica, sans-serif;"><a href="http://karinlab-et-al.blogspot.com/2012/02/e3-ubiquitin-ligase-itch-couples-jnk.html">Cell. 2006 Feb 10;124(3):601-13.</a></b><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pubpeer: </span><a href="https://pubpeer.com/publications/16469705" style="font-family: Arial, Helvetica, sans-serif;">https://pubpeer.com/publications/16469705</a><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-color: white; background-image: initial; background-origin: initial;"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">5</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><a href="http://karinlab-et-al.blogspot.com/2012/02/alternative-and-classical-nf-kappa-b.html">Immunity. 2006 Sep;25(3):403-15.</a></b><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/16973390">https://pubpeer.com/publications/16973390</a></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">6</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 19px;"><b>Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1717-22.</b></span></span><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/16446428">https://pubpeer.com/publications/16446428</a></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-color: white; background-image: initial; background-origin: initial;"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">7</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333; line-height: 24px;"><span style="background-color: white; line-height: 19px;"> </span></span></span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;"><a href="http://karinlab-et-al.blogspot.com/2012/02/nuclear-cytokine-activated-ikkalpha.html">Nature. 2007 Apr 5;446(7136):690-4.</a></span></span></b><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/17377533">https://pubpeer.com/publications/17377533</a></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-color: white; background-image: initial; background-origin: initial;"><span style="line-height: 24px;">Article No.</span><span style="line-height: 14px;">6</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333; line-height: 24px;"><span style="line-height: 19px;"> </span></span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333; line-height: 24px;"><span style="background-color: white; line-height: 19px;"> </span></span></span></b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;"><b><a href="http://karinlab-et-al.blogspot.com/2012/02/ikkalpha-is-critical-coregulator-of.html">Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2487-92.</a></b></span></span><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/18268325">https://pubpeer.com/publications/18268325</a></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-color: white; background-image: initial; background-origin: initial;"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">7</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333; line-height: 24px;"><span style="background-color: white; line-height: 19px;"> </span></span></span></b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;"><b><a href="http://karinlab-et-al.blogspot.com/2012/02/nod2-nalp1-complex-mediates-caspase-1.html">Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7803-8.</a></b></span></span><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: <a href="https://pubpeer.com/publications/18511561">https://pubpeer.com/publications/18511561</a></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">8</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333; line-height: 24px;"><span style="line-height: 19px;"> </span></span></span></b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 19px;"><b>Cancer Cell. 2010 Mar 16;17(3):286-97.</b></span></span><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: </span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><a href="https://pubpeer.com/publications/20227042">https://pubpeer.com/publications/20227042</a></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">9</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333; line-height: 24px;"><span style="line-height: 19px;"> </span></span></span></b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 19px;"><b>J Exp Med. 2011 Aug 29;208(9):1889-900.</b></span></span><br />
<span style="background-color: white;"><span style="background-color: transparent; color: #333333; font-family: Arial, Helvetica, sans-serif;">PubPeer: </span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 19px;"><a href="https://pubpeer.com/publications/21825016">https://pubpeer.com/publications/21825016</a></span></span><br />
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; color: #333333;"><span lang="EN-US"><span style="line-height: 24px;">Article No.</span><span style="line-height: 17px;">10</span></span></span></span></b><b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">:</span></b><b style="color: #333333; font-family: Arial, Helvetica, sans-serif; line-height: 24px;"><span style="background-color: white; color: #333333;"><span style="line-height: 19px;"> </span></span></b><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 19px;"><b>Nature. 2012 Nov 8;491(7423):254-8.</b></span></span><br />
<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">Pub</span><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif;">P</span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;">eer: </span><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><a href="https://pubpeer.com/publications/23034650">https://pubpeer.com/publications/23034650</a></span><br />
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<span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;"><br /></span></span>11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com1tag:blogger.com,1999:blog-8676192399007759951.post-9518513149505107192012-02-11T07:59:00.001+09:002013-05-07T08:47:15.690+09:00Jun turnover is controlled through JNK-dependent phosphorylation of theE3 ligase Itch.<br />
<div class="cit" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; font: inherit; line-height: 1.45em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a abstractlink="yes" alsec="jour" alterm="Science." href="http://www.ncbi.nlm.nih.gov/pubmed/15358865#" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" title="Science (New York, N.Y.).">Science.</a> 2004 Oct 8;306(5694):271-5. Epub 2004 Sep 9.</div>
<h1 style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 1.3846em; font: inherit; line-height: 1.125em; margin-bottom: 0.375em; margin-left: 0px; margin-right: 0px; margin-top: 0.375em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<b><span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Jun</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">turnover</span> is <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">controlled</span> through <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">JNK-dependent</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">phosphorylation</span> of the<span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">E3 ligase</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Itch</span>.</b></h1>
<div class="auths" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.923em; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gao%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Gao M</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Labuda%20T%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Labuda T</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Xia%20Y%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Xia Y</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gallagher%20E%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Gallagher E</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Fang%20D%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Fang D</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Liu%20YC%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Liu YC</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Karin%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Karin M</a>.</div>
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Source</h3>
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Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA.</div>
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Source</h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh0EW_7ukk8KH8hRiq3bhK9oHr8t5T_npObrCm0oyAPqOkpI9BLo6Bhd8f0Tc86mGiCQNmXp-IZ9czvCP6r1Xce0yGR3f8LHBvA3M2v-2FtKhn6NamdWgKoisx4YafK6ed1Ib9thcMvSfZS/s1600/Science+2004+Fig3.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="376" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh0EW_7ukk8KH8hRiq3bhK9oHr8t5T_npObrCm0oyAPqOkpI9BLo6Bhd8f0Tc86mGiCQNmXp-IZ9czvCP6r1Xce0yGR3f8LHBvA3M2v-2FtKhn6NamdWgKoisx4YafK6ed1Ib9thcMvSfZS/s400/Science+2004+Fig3.jpg" width="400" /></a></div>
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Source</h3>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-8676192399007759951.post-18375071816122948302012-02-11T07:56:00.000+09:002014-04-30T04:54:21.389+09:00A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.<br />
<div class="cit" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; font: inherit; line-height: 1.45em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a abstractlink="yes" alsec="jour" alterm="Mol Cell." href="http://www.ncbi.nlm.nih.gov/pubmed/15175153#" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" title="Molecular cell.">Mol Cell.</a> 2004 Jun 4;14(5):571-83.</div>
<h1 style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 1.3846em; font: inherit; line-height: 1.125em; margin-bottom: 0.375em; margin-left: 0px; margin-right: 0px; margin-top: 0.375em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<b>A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.</b></h1>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gherzi%20R%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Gherzi R</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Lee%20KY%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Lee KY</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Briata%20P%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Briata P</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Wegm%C3%BCller%20D%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Wegmüller D</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Moroni%20C%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Moroni C</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Karin%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Karin M</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Chen%20CY%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Chen CY</a>.</div>
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Source</h3>
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Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132 Genoa, Italy. rgherzi@yahoo.com</div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-8676192399007759951.post-80025959347487546342012-02-11T06:53:00.002+09:002014-05-02T06:27:31.215+09:00The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.<br />
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<a abstractlink="yes" alsec="jour" alterm="Cell." href="http://www.ncbi.nlm.nih.gov/pubmed/16469705#" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" title="Cell.">Cell.</a> 2006 Feb 10;124(3):601-13.</div>
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<b>The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.</b></h1>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Chang%20L%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Chang L</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kamata%20H%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Kamata H</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Solinas%20G%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Solinas G</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Luo%20JL%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Luo JL</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Maeda%20S%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Maeda S</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Venuprasad%20K%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Venuprasad K</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Liu%20YC%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Liu YC</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Karin%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Karin M</a>.</div>
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Division of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E. Duarte Road, KCRB 3009, Duarte, CA 91010, USA.</div>
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<b>Fig. 2 - <a href="http://www.sciencedirect.com/cache/MiamiImageURL/1-s2.0-S0092867406001139-gr2_lrg.jpg/0?wchp=dGLzVlV-zSkzS">View high quality image (639K)</a></b></div>
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<span style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; line-height: normal;">Cells in Fig.3D look very similar to cells in Fig.4A, but they are supposed to be of different genotypes, and transfected and treated differently.</span><br style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; line-height: normal; outline: none;" /><a href="http://imgur.com/2A2CUHV" style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; line-height: normal; outline: none; text-decoration: none;" target="_blank">http://imgur.com/2A2CUHV</a></div>
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<span style="font-family: Open Sans, sans-serif;"><span style="font-size: 14.545454025268555px;"><a href="https://pubpeer.com/publications/26BF1A9A41412947E05D956E91F161#fb8052">https://pubpeer.com/publications/26BF1A9A41412947E05D956E91F161#fb8052</a></span></span></div>
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<span style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit;"><br /></span></div>
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<span style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit;">In Fig. 1A, the 12.5 day WT and double mutant embryos are the same. See the identical light reflections. </span><br style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; outline: none;" /><br style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; outline: none;" /><a href="http://i.imgur.com/oEWRbgg.png" style="background-color: #f0f0f0; font-family: 'Open Sans', sans-serif; font-size: 14.666666984558105px; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; outline: none; text-decoration: none;" target="_blank">http://i.imgur.com/oEWRbgg.png</a></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-8676192399007759951.post-77425288738911350852012-02-11T06:27:00.001+09:002012-02-11T06:41:38.850+09:00Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.<br />
<div class="cit" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
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<a abstractlink="yes" alsec="jour" alterm="Nature." href="http://www.ncbi.nlm.nih.gov/pubmed/17377533#" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" title="Nature.">Nature.</a> 2007 Apr 5;446(7136):690-4. Epub 2007 Mar 18.</div>
<h1 style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 1.3846em; font: inherit; line-height: 1.125em; margin-bottom: 0.375em; margin-left: 0px; margin-right: 0px; margin-top: 0.375em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">
<b>Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.</b></h1>
<div class="auths" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.923em; font: inherit; line-height: 1.45em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Luo%20JL%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Luo JL</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Tan%20W%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Tan W</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Ricono%20JM%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Ricono JM</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Korchynskyi%20O%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Korchynskyi O</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Zhang%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Zhang M</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gonias%20SL%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Gonias SL</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Cheresh%20DA%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Cheresh DA</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Karin%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Karin M</a>.</div>
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Source</h3>
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Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA.</div>
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<b>Erratum in</b></h3>
<ul style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 14px; font: inherit; line-height: 15px; list-style-image: initial; list-style-position: outside; list-style-type: none; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">
<li style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; display: block; font-size: 14px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Nature. 2009 Feb 12;457(7231):920.</li>
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<span style="background-color: #efefef; font-family: arial, helvetica, clean, sans-serif; font-size: 14px; line-height: normal; text-align: -webkit-auto;">It has come to our attention that some of the control lanes in Fig. 2a (Kai1 and Mkk4 control lanes) may </span><br style="background-color: #efefef; line-height: normal; text-align: -webkit-auto;" /><span style="background-color: #efefef; font-family: arial, helvetica, clean, sans-serif; font-size: 14px; line-height: normal; text-align: -webkit-auto;">have been inadvertently duplicated during figure assembly; </span><br style="background-color: #efefef; line-height: normal; text-align: -webkit-auto;" /><span style="background-color: #efefef; font-family: arial, helvetica, clean, sans-serif; font-size: 14px; line-height: normal; text-align: -webkit-auto;">the other control lanes and the experimental Maspin lanes are correct. </span><br style="background-color: #efefef; line-height: normal; text-align: -webkit-auto;" /><span style="background-color: #efefef; font-family: arial, helvetica, clean, sans-serif; font-size: 14px; line-height: normal; text-align: -webkit-auto;">We have therefore repeated the experiments and obtained the same results as those in the published figure. </span><br style="background-color: #efefef; line-height: normal; text-align: -webkit-auto;" /><span style="background-color: #efefef; font-family: arial, helvetica, clean, sans-serif; font-size: 14px; line-height: normal; text-align: -webkit-auto;">The primary data from this experiment can be found in Supplementary Information. </span><br style="background-color: #efefef; line-height: normal; text-align: -webkit-auto;" /><br /><br /><br style="background-color: #efefef; line-height: normal; text-align: -webkit-auto;" />どこが複製されている画像なのでしょうか? </div>
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</div>11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com2tag:blogger.com,1999:blog-8676192399007759951.post-8282014104881245312012-02-11T01:14:00.000+09:002012-02-12T10:40:18.994+09:00Alternative and classical NF-kappa B signaling retain autoreactive B cells in thesplenic marginal zone and result in lupus-like disease.<br />
<div class="cit" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; font: inherit; line-height: 1.45em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a abstractlink="yes" alsec="jour" alterm="Immunity." href="http://www.ncbi.nlm.nih.gov/pubmed?term=Alternative%20and%20Classical%20NF-kB%20Signaling%20Retain%20Autoreactive%20B%20Cells%20in%20the%20Splenic%20Marginal%20Zone%20and%20Result%20in%20Lupus-like%20Disease#" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" title="Immunity.">Immunity.</a> 2006 Sep;25(3):403-15.</div>
<h1 style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 1.3846em; font: inherit; line-height: 1.125em; margin-bottom: 0.375em; margin-left: 0px; margin-right: 0px; margin-top: 0.375em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<b><span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Alternative</span> and <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">classical</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">NF-kappa B</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">signaling</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">retain</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">autoreactive</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">B cells</span> in the<span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">splenic</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">marginal</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">zone</span> and <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">result</span> in <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">lupus-like</span> <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 19px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">disease</span>.</b></h1>
<div class="auths" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.923em; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Enzler%20T%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Enzler T</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Bonizzi%20G%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Bonizzi G</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Silverman%20GJ%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Silverman GJ</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Otero%20DC%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Otero DC</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Widhopf%20GF%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Widhopf GF</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Anzelon-Mills%20A%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Anzelon-Mills A</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Rickert%20RC%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Rickert RC</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Karin%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Karin M</a>.</div>
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Source</h3>
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Laboratory of Gene Regulation and <span class="highlight" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Signal Transduction</span>, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.</div>
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</div>11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-8676192399007759951.post-78750909635712891952012-02-10T23:13:00.000+09:002012-02-13T01:30:54.298+09:00A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.<br />
<div class="cit" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; font: inherit; line-height: 1.45em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a abstractlink="yes" alsec="jour" alterm="Proc Natl Acad Sci U S A." href="http://www.ncbi.nlm.nih.gov/pubmed/18511561#" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" title="Proceedings of the National Academy of Sciences of the United States of America.">Proc Natl Acad Sci U S A.</a> 2008 Jun 3;105(22):7803-8. Epub 2008 May 29.</div>
<h1 style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 1.3846em; font: inherit; line-height: 1.125em; margin-bottom: 0.375em; margin-left: 0px; margin-right: 0px; margin-top: 0.375em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<b>A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.</b></h1>
<div class="auths" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.923em; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Hsu%20LC%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Hsu LC</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Ali%20SR%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Ali SR</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22McGillivray%20S%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">McGillivray S</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Tseng%20PH%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Tseng PH</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Mariathasan%20S%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Mariathasan S</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Humke%20EW%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Humke EW</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Eckmann%20L%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Eckmann L</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Powell%20JJ%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Powell JJ</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Nizet%20V%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Nizet V</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Dixit%20VM%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Dixit VM</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Karin%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Karin M</a>.</div>
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Source</h3>
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Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA. lichunghsu@ntu.edu.tw</div>
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<a href="http://www.pnas.org/content/105/22/7803/F3.expansion.html">Fig. 3</a></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg900BNknwrDS03c11XfyClS8gEBapNf_7lG4hdpR7aCnopHh4s-v3wKhFP2iGFnmCN_qx0PgD7JSaefUB6hr6WkRtJVOm_q3Sn8FvG1JMPcsjeYFsV9kkk75Qek7S8jdr2cB5Nbe3ch2pN/s1600/PNAS+2008+Jun+Fig3E.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg900BNknwrDS03c11XfyClS8gEBapNf_7lG4hdpR7aCnopHh4s-v3wKhFP2iGFnmCN_qx0PgD7JSaefUB6hr6WkRtJVOm_q3Sn8FvG1JMPcsjeYFsV9kkk75Qek7S8jdr2cB5Nbe3ch2pN/s400/PNAS+2008+Jun+Fig3E.jpg" width="353" /></a></div>
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</div>11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-8676192399007759951.post-12102874498426623722012-02-10T21:22:00.000+09:002012-02-13T01:31:24.931+09:00IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.<br />
<div class="cit" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; font: inherit; line-height: 1.45em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
<a abstractlink="yes" alsec="jour" alterm="Proc Natl Acad Sci U S A." href="http://www.ncbi.nlm.nih.gov/pubmed/18268325#" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 11px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" title="Proceedings of the National Academy of Sciences of the United States of America.">Proc Natl Acad Sci U S A.</a> 2008 Feb 19;105(7):2487-92. Epub 2008 Feb 11.</div>
<h1 style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font-size: 1.3846em; font: inherit; line-height: 1.125em; margin-bottom: 0.375em; margin-left: 0px; margin-right: 0px; margin-top: 0.375em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.</h1>
<div class="auths" style="background-color: white; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: arial, helvetica, clean, sans-serif; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; vertical-align: baseline;">
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<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Descargues%20P%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Descargues P</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sil%20AK%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Sil AK</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sano%20Y%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Sano Y</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Korchynskyi%20O%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Korchynskyi O</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Han%20G%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Han G</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Owens%20P%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Owens P</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Wang%20XJ%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Wang XJ</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Karin%20M%22%5BAuthor%5D" style="border-bottom-color: initial; border-bottom-style: initial; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #660066; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Karin M</a>.</div>
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<span style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 11px; line-height: 1.0915em;">Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA.</span></div>
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<a href="http://www.pnas.org/content/105/7/2487/F2.large.jpg">Fig. 2B</a><br />
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<h3 class="label" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #724128; font-size: 1.0769em; font: inherit; height: 1px; left: -10000px; line-height: 1.2857; margin-bottom: 0.6428em; margin-left: 0px; margin-right: 1em; margin-top: 1.2856em; outline-color: initial; outline-style: initial; outline-width: 0px; overflow-x: hidden; overflow-y: hidden; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; position: absolute; top: auto; vertical-align: baseline; width: 1px;">
<br class="Apple-interchange-newline" />Source</h3>
<div class="separator" style="clear: both; font-size: 0.923em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhfbcna3koSwL2COPmrBzz0M8wfAA4NsEF1WCA4k3QIbAyhrNMp3G4xpKU4osG5uK9YStu6efiaz_kJDehyGuMYuX7bsk4DXUeFVY9INIi67P7xtfAuTYhXgZCTf7E06bXHB7VpbWYT2RrQ/s1600/PNAS+2008+Feb+Fig2B.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhfbcna3koSwL2COPmrBzz0M8wfAA4NsEF1WCA4k3QIbAyhrNMp3G4xpKU4osG5uK9YStu6efiaz_kJDehyGuMYuX7bsk4DXUeFVY9INIi67P7xtfAuTYhXgZCTf7E06bXHB7VpbWYT2RrQ/s400/PNAS+2008+Feb+Fig2B.jpg" width="225" /></a></div>
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<h3 class="label" style="border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #724128; font-size: 1.0769em; font: inherit; height: 1px; left: -10000px; line-height: 1.2857; margin-bottom: 0.6428em; margin-left: 0px; margin-right: 1em; margin-top: 1.2856em; outline-color: initial; outline-style: initial; outline-width: 0px; overflow-x: hidden; overflow-y: hidden; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; position: absolute; top: auto; vertical-align: baseline; width: 1px;">
<br class="Apple-interchange-newline" />Source</h3>
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<a href="http://www.pnas.org/content/105/7/2487/F4.large.jpg">Fig. 4</a></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj9hGGynKuFLam7jo3uehdca1xffD4JEcx_E_Voew0P0j_tEtO_gH1VK18TK2-Cnyc1TpNr0FmX7O1CT0EjJ07AZsLASC9X2HdYjMAdUZE19mM2a_Q-FWXTRgEjakPB6xHzxinBNjcnle2C/s1600/PNAS+2008+Feb+Fig4A.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj9hGGynKuFLam7jo3uehdca1xffD4JEcx_E_Voew0P0j_tEtO_gH1VK18TK2-Cnyc1TpNr0FmX7O1CT0EjJ07AZsLASC9X2HdYjMAdUZE19mM2a_Q-FWXTRgEjakPB6xHzxinBNjcnle2C/s320/PNAS+2008+Feb+Fig4A.jpg" width="266" /></a></div>
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<br class="Apple-interchange-newline" />Source</h3>
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</div>11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0